Project Title: Genotype-informed Versus Empiric Management Of VirEmia (GIVE MOVE): An open-label Randomised Clinical Trial

Project Description: Children and adolescents are highly vulnerable to adverse health consequences caused by HIV. Unlike adults, children and adolescents living with HIV (CALHIV) and receiving antiretroviral therapy (ART) in sub Saharan Africa suffer high rates of treatment failure (approx 25-40%). Treatment failure may be caused by non-adherence to therapy, incorrect drug dosing, or viral drug resistance. GRT is a diagnostic test to detect drug resistance, allowing for an informed selection of drugs that will be effective... Children and adolescents are highly vulnerable to adverse health consequences caused by HIV. Unlike adults, children and adolescents living with HIV (CALHIV) and receiving antiretroviral therapy (ART) in sub Saharan Africa suffer high rates of treatment failure (approx 25-40%). Treatment failure may be caused by non-adherence to therapy, incorrect drug dosing, or viral drug resistance. GRT is a diagnostic test to detect drug resistance, allowing for an informed selection of drugs that will be effective in the respective patient. We intend to assess the effect of GRT-informed management of unsuppressed viremia on subsequent health outcomes in children and adolescents living with HIV. GIVE MOVE is randomised clinical trial enrolling 276 HIV- positive children and adolescents with viremia while on first-line antriretrial therapy. Enrolment will take place in two countries (Tanzania and Lesotho), and enrolled participants will be randomised in a 1.1 allocation to the control or intervention arm. The control arm will receive the standard of care (Enhanced adherence counselling, repeat viral load testing after 3 consecutive EAC, and empirical choice of onward therapy, Primary outcomes will be assessed 36 weeks(window: 32-44 weeks) after enrolment. Read more

Principal Investigator : Ezekiel Luoga

Department Name : BRCT

Time frame: (2020-01-06) - (2022-11-30)

Funding Partners
Botnar Foundation (Prime)
Swiss Tropical and Public Health Institute (Normal)
External Collaborating Partners
None added yet.